13q染色体缺失增加视网膜母细胞瘤患者化

　　年7月13日，美国儿科血液学与肿瘤学会、国际儿科肿瘤学会、国际小儿外科肿瘤学会、组织细胞学会、欧洲儿科血液学与免疫学会、日本儿科血液学与肿瘤学会官方期刊《儿科血液与癌症》在线发医院、田纳西大学健康科学中心的研究报告，发现13q染色体缺失的视网膜母细胞瘤患者中性粒细胞减少发生率较高，需要减少化疗（长春新碱＋卡铂或托泊替康）剂量，但是并不增加治疗失败率。

PediatrBloodCancer.Jul13.[Epubaheadofprint]

Patientswithretinoblastomaandchromosome13qdeletionshaveincreasedchemotherapy-relatedtoxicities.

BrennanRC,QaddoumiI,BillupsCA,KaluznyT,FurmanWL,WilsonMW.

St.JudeChildrensResearchHospital,Memphis,Tennessee;UniversityofTennesseeHealthScienceCenter,Memphis,Tennessee.

BACKGROUND:Atotalof5-10%ofpatientswithretinoblastoma(RB)harbordeletionofthelongarm(q)chromosome13(13q-).Thetreatment-relatedtoxicitiesinthispopulationhavenotbeendescribed.

METHODS:Sixty-eightRBpatientsonasingleinstitutionalprotocol(RET5)fromtowerereviewed.Geneticscreeningidentified11patients(sevenfemale)with13q-.Patientswithearly(Reese-Ellsworth[R-E]groupI-III)disease(6/23with13q-)receivedeightcoursesofvincristine/carboplatin(VC).Patientswithadvanced(R-EgroupIV-V)bilateraldisease(2/27with13q-)receivedtwocoursesofvincristine/topotecan(VT)followedbyninecoursesofalternatingVT/VC.Patientsundergoingupfrontenucleationreceivedhistopathology-basedchemotherapy:intermediaterisk(2/8with13q-)orhighrisk(1/10with13q-).Dosereductionsweremandatedfor7daydelayintwoconsecutivecoursesfollowinghematologictoxicity.Grades3and4hematologic,infectious,andgastrointestinaltoxicitieswere







































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